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Case Reports
Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy: A Case Report.
- Daisuke Himeji, Gen-Ichi Tanaka, Ritsuya Shiiba, Ryoichi Matsumoto, Kazuhiro Takamura, Hirotaka Morishita, Shuichi Taniguchi, Sayaka Moriguchi, and Kousuke Marutsuka.
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan.
- Intern. Med. 2022 Jan 15; 61 (2): 217-221.
AbstractWe herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carboplatin therapy. On receiving olaparib, she showed symptoms of a fever and malaise. Based on laboratory and imaging findings, she was diagnosed with PCP. After treatment with corticosteroids and trimethoprim/sulfamethoxazole followed by atovaquone, the patient's general condition improved. The lymphocytopenia observed after olaparib administration may have been associated with the development of PCP.
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