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Review
Resuscitation Guided by Volume Responsiveness Does Not Reduce Mortality in Sepsis: A Meta-Analysis.
- Robert R Ehrman, John Z Gallien, Reid K Smith, Katherine G Akers, Adrienne N Malik, Nicholas E Harrison, Robert D Welch, Phillip D Levy, and Robert L Sherwin.
- Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI.
- Crit Care Explor. 2019 May 1; 1 (5): e0015.
AbstractResuscitation with IV fluids is a critical component in the management of sepsis. Although the optimal volume of IV fluid is unknown, there is evidence that excessive administration can be deleterious. Static measures of volume status have not proven to be meaningful resuscitative endpoints. Determination of volume responsiveness has putative benefits over static measures, but its effect on outcomes is unknown. The goal of this systematic review and meta-analysis was to determine if resuscitation with a volume responsiveness-guided approach leads to improved outcomes in septic patients.Copyright (c) 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
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