• Adv Healthc Mater · Jun 2015

    Review

    Biomaterials for Bone Regenerative Engineering.

    • Xiaohua Yu, Xiaoyan Tang, Shalini V Gohil, and Cato T Laurencin.
    • Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
    • Adv Healthc Mater. 2015 Jun 24; 4 (9): 1268-85.

    AbstractStrategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the "tissue engineering" concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as "regenerative engineering". In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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