• Ophthal Plast Reconstr Surg · Mar 2004

    Monoclonal antibody treatment of orbital lymphoma.

    • Timothy J Sullivan, David Grimes, and Ian Bunce.
    • Department of Ophthalmology, University of Queensland, Royal Brisbane Hospital, Herston, Queensland, Australia. tjs@gil.com.au
    • Ophthal Plast Reconstr Surg. 2004 Mar 1; 20 (2): 103-6.

    PurposeTo describe the use of an anti-CD20 monoclonal antibody, Rituximab, in the treatment of orbital lymphoma.MethodsProspective, noncomparative, interventional case series of 8 patients treated with rituximab. Management, side effects, and outcome were recorded.ResultsFive patients had initial complete response, 2 had partial response, and 1 had no response to this treatment. One patient had breathlessness, bronchospasm, and hypotension but was able to complete treatment. Mean follow-up was 16.5 months (range, 6 to 32 months).ConclusionsRituximab is a safe and effective treatment in some cases of orbital lymphoma and may be used as an alternative to, or in conjunction with, other therapeutic modalities.

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