• Tatsuya Ichinohe and Yuzuru Kaneko.
• Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan. ichinohe@tdc.ac.jp
• J. Oral Maxillofac. Surg. 2007 May 1;65(5):936-9.

PurposeThe purpose of this study was to evaluate the effect of supplemental nitrous oxide on postoperative nausea and vomiting (PONV) after propofol anesthesia for orthognathic surgery in female and nonsmoking patients.Patients And MethodsWe compared PONV in 28 ASA-I female nonsmoking patients undergoing orthognathic surgery. Anesthesia was induced with propofol combined with fentanyl, and tracheal intubation was facilitated with vecuronium. Anesthesia was maintained with propofol with or without nitrous oxide. No patient received neostigmine. PONV was assessed as score 0 (no PONV), score 1 (nausea), and score 2 (vomiting) during the 24-hour recovery period.ResultsThere were no differences in the patients' characteristics, operation, anesthesia and emergence time, fluid transfusion, blood loss, urine output, and total propofol and fentanyl doses between the 2 groups. There was also no difference in PONV score in 2 groups. Only 1 patient in each group vomited.ConclusionsIt is suggested that supplemental nitrous oxide does not aggravate PONV after propofol anesthesia for orthognathic surgery in female nonsmoking patients.

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