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Seminars in oncology · Feb 1997
ReviewTopotecan and the treatment of recurrent ovarian cancer: is there a role for granulocyte colony-stimulating factor?
- L Saltz and J E Janik.
- Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
- Semin. Oncol. 1997 Feb 1; 24 (1 Suppl 5): S5-26-S5-30.
AbstractTopotecan (Hycamtin; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) a new chemotherapeutic agent for the treatment of patients with advanced carcinoma of the ovary after failure of initial or subsequent therapy, is a specific, potent inhibitor of the enzyme topoisomerase I. Myelosuppression is the dose-limiting toxicity of topotecan, and can interfere with the administration of the recommended dose/schedule of the drug by delaying the next cycle of chemotherapy or by requiring a reduction in the dose. The results from clinical studies suggest that routine granulocyte colony-stimulating factor therapy is not needed when topotecan is administered at the recommended dose of 1.5 mg/m2/d for 5 days. However, patients should be carefully monitored, as some may benefit from hematopoietic growth factor support on subsequent cycles.
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