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Case Reports
Ciprofloxacin-induced immune-mediated thrombocytopenia: No cross-reactivity with gemifloxacin.
- D W Sim, J E Yu, J Jeong, and Y-I Koh.
- Division of Allergy, Asthma and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- J Clin Pharm Ther. 2018 Feb 1; 43 (1): 134-136.
What Is Known And ObjectiveFluoroquinolone-induced immune-mediated thrombocytopenia is uncommon, and no reports of cross-reactivity among fluoroquinolones exist. Here, we describe a case of ciprofloxacin-induced immune thrombocytopenia with no cross-reactivity with gemifloxacin.Case DescriptionA 77-year-old woman showed profound thrombocytopenia immediately after two ciprofloxacin injections for pneumonia. Platelet counts recovered rapidly after ciprofloxacin discontinuation. She had experienced thrombocytopenia after ciprofloxacin administration 4 years earlier, which was assumed to be ciprofloxacin-induced immune-related. Interestingly, no thrombocytopenia occurred following the subsequent exposure to another fluoroquinolone, gemifloxacin.What Is New And ConclusionNo cross-reactivity occurred between ciprofloxacin and gemifloxacin in this fluoroquinolone-induced immune thrombocytopenia case.© 2017 John Wiley & Sons Ltd.
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