• QJM · Oct 2009

    Case Reports

    A case of ST-elevation and nystagmus--when coronary thrombosis is not to blame.

    • M J Daly and L J Dixon.
    • The Heart Centre, Royal Victoria Hospital, Belfast, Northern Ireland, UK. michaeljdaly@hotmail.com
    • QJM. 2009 Oct 1; 102 (10): 737-9.

    AbstractWe present the case of a post-menopausal female who, following a prolonged period of vomiting and diarrhoea, presented acutely with Wernicke's; encephalopathy, chest pain, ST-segment elevation and congestive cardiac failure associated with hypotension. Coronary angiography demonstrated no abnormality. Haemodynamics improved significantly in the short-term following intravenous thiamine replacement, with complete resolution of all ST-segment abnormalities and normalization of left ventricular function at six-week follow-up. Shoshin beriberi in the context of metabolic alkalosis, secondary to severe electrolyte depletion, is exceptional and is a differential diagnosis to be considered in all malnourished patients presenting with symptoms and signs suggestive of an acute coronary syndrome, especially those with a history of alcohol-dependence.

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