• Lambertenghi DeliliersGGCentro Trapianti di Midollo, Ospedale Maggiore di Milano, I.R.C.C.S. Università degli Studi di Milano, Italy., C Annaloro, A Della Volpe, A Oriani, R Mozzana, E Pozzoli, E Tagliaferri, and D Soligo.
• Centro Trapianti di Midollo, Ospedale Maggiore di Milano, I.R.C.C.S. Università degli Studi di Milano, Italy.
• Haematologica. 1995 Mar 1; 80 (2): 136-41.

BackgroundCurrent results of autologous bone marrow transplantation (ABMT) suggest that this procedure may prolong disease-free survival (DFS) in patients with acute myeloid leukemia (AML).Materials And MethodsOver the last ten years, 29 AML patients received unpurged autologous bone marrow (BM) after a conditioning regimen including Ara-C (3 g/m2/12h, days -9, -8), CTX (60 mg/kg/day, days -6, -5) and TBI (3.33 Gy/day, days -3 through -1). In 21 patients, ABMT was performed as late intensification after first CR. Eight more relapsing patients were autografted after the achievement of second CR.ResultsThree patients died from transplant-related complications. In the remaining patients, mean times to WBC and platelet recovery were, respectively, 23 days (range 13-55) and 55 days (range 22-790). Follow-up for censored patients ranged from 1 to 120 months. Relapse occurred in 7 patients (5 in first and 2 in second CR). Overall 5-year DFS and event-free survival (EFS) chances were, respectively, 67.3% and 60%, with no statistically significant differences between first (DFS = 67.3%, EFS = 60.3%) and second CR (DFS = 68.6%, EFS = 60%).DiscussionApart from obvious selection biases, our study suggests that outcome in first CR AML patients is improved by ABMT. Long-term DFS and EFS are clearly better than when conventional post-remission chemotherapies are used. The greater antileukemic potential of ABMT is further underlined by the results in patients autografted in second CR, when conventional chemotherapy is almost never curative.

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