• Kenneth Mangion, Andrew Morrow, Catherine Bagot, Hannah Bayes, Kevin G Blyth, Colin Church, David Corcoran, Christian Delles, Lynsey Gillespie, Douglas Grieve, Antonia Ho, Sharon Kean, Ninian N Lang, Vera Lennie, David J Lowe, Peter Kellman, Peter W Macfarlane, Alex McConnachie, Giles Roditi, Robert Sykes, Rhian M Touyz, Naveed Sattar, Ryan Wereski, Sylvia Wright, and Colin Berry.
• British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
• Cardiovasc. Res. 2020 Dec 1; 116 (14): 2185-2196.

BackgroundCOVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear.MethodsThis is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation.ConclusionCISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.Clinical Trial RegistrationClinicalTrials.gov identifier NCT04403607.© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.

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