• J. Am. Acad. Dermatol. · May 2007

    Case Reports

    Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.

    • Diona L Damian and John F Thompson.
    • Department of Dermatology, University of Sydney at Royal Prince Alfred Hospital, Australia. diona.damian@email.cs.nsw.gov.au
    • J. Am. Acad. Dermatol. 2007 May 1; 56 (5): 869-71.

    AbstractDiphencyprone is a potent contact sensitizer sometimes used to treat alopecia areata and cutaneous warts. A patient with previous primary nodular melanoma on the scalp developed extensive, confluent cutaneous metastases near the primary site, unsuitable for treatment with surgery or radiotherapy. Topical treatment with diphencyprone as a single agent resulted in regression of all lesions, and the patient remains well 18 months later. Topical immunotherapy with diphencyprone was an inexpensive and well-tolerated treatment for extensive cutaneous melanoma metastases in our patient unsuitable for other therapies.

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