• Sophia Wang, Heidi Lindroth, Carol Chan, Ryan Greene, Patricia Serrano-Andrews, Sikandar Khan, Gabriel Rios, Shiva Jabbari, Joanna Lim, Andrew J Saykin, and Babar Khan.
• Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana.
• J Am Geriatr Soc. 2021 Jan 1; 69 (1): 255-263.

ObjectivesTo identify whether delirium biomarkers aligned with the National Institute on Aging-Alzheimer's Association (NIA-AA) research framework, a conceptual model that describes the use of diagnostic biomarkers for Alzheimer's disease and other related dementias (ADRD).DesignSystematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.SettingAcute care and outpatient settings.ParticipantsAdults diagnosed with delirium.Methods And MeasurementsMEDLINE, PsycInfo, Embase, and the Cochrane Library were searched for English-language studies published from January 2010 to February 2020. Studies included adults older than 18 years, identified delirium with a standardized assessment tool, and measured an ADRD biomarker. Independent reviewers determined whether an association between delirium and ADRD biomarker was found, the quality of biomarker data based on the REMARK (REporting recommendations for tumor MARKer prognostic studies) checklist, and the study bias based on the Newcastle-Ottawa Scale.ResultsA total of 61,256 citations were identified; 113 studies were included. Most studies did not examine amyloid, tau, or neurodegeneration biomarkers. Delirium may be associated with neurodegeneration biomarkers, but few to no studies found an association with amyloid and tau biomarkers. Delirium was not consistently associated with inflammatory biomarkers. The quality of biomarker data was moderate, and the risk of bias was moderate to high. Studies often did not collect prehospital and posthospital cognitive data.ConclusionMost delirium diagnostic biomarker studies did not measure amyloid, tau, and/or neurodegenerative biomarkers, making characterization of the relationship between delirium and ADRD difficult. Future delirium biomarker diagnostic studies could improve the understanding of pathophysiologic links between delirium with other conditions affecting cognition.© 2020 The American Geriatrics Society.

20 keywords...

hide…