• Guillaume Costentin, Ozlem Ozkul-Wermester, Aude Triquenot, Véronique Le Cam-Duchez, Nathalie Massy, Ygal Benhamou, and Evelyne Massardier.
• Department of Neurology, Rouen University Hospital, Rouen F-76000, France. Electronic address: guillaume.costentin@chu-rouen.fr.
• J Stroke Cerebrovasc Dis. 2021 Sep 1; 30 (9): 105942.

AbstractVaccine-induced immune thrombotic thrombocytopenia is a rare syndrome following the ChAdOx1 nCov-19 or Ad26.COV2.S vaccine. Reported patients developed mainly venous thrombosis. We describe a case of a young healthy women suffering from acute ischemic stroke due to large vessel occlusion without cerebral venous thrombosis 8 days after vaccination and its consequences on recanalization strategy. Considering the thrombocytopenia, intravenous thrombolysis was contraindicated. She underwent mechanical thrombectomy with complete recanalization and dramatically improved clinically. Positive detection of anti-PF4-heparin-antibodies confirmed vaccine-induced immune thrombotic thrombocytopenia diagnosis. In case of acute ischemic stroke after recent ChAdOx1 nCov-19 or Ad26.COV2.S vaccine, platelet count should be systematically checked before giving thrombolysis, and direct mechanical thrombectomy should be proposed in patients with large vessel occlusion.Copyright © 2021 Elsevier Inc. All rights reserved.

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