• Henriette J Tschampa, Horst Urbach, Michael Malter, Rainer Surges, Susanne Greschus, and Jürgen Gieseke.
• Department of Radiology/Neuroradiology, University of Bonn, Bonn, Germany. Electronic address: Henriette.Tschampa@ukb.uni-bonn.de.
• Epilepsy Res. 2015 Oct 1; 116: 8-14.

PurposeFocal cortical dysplasia (FCD) is a frequent finding in drug resistant epilepsy. The aim of our study was to evaluate an isotropic high-resolution 3-dimensional Fluid-attenuated inversion recovery sequence (3D FLAIR) at 3T in comparison to standard 2D FLAIR in the diagnosis of FCD.Materials And MethodsIn a prospective study, 19 epilepsy patients with the MR diagnosis of FCD were examined with a sagittal 3D FLAIR sequence with modulated refocusing flip angle (slice thickness 1.10mm) and a 2D FLAIR in the coronal (thk. 3mm) and axial planes (thk. 2mm). Manually placed regions of interest were used for quantitative analysis. Qualitative image analysis was performed by two neuroradiologists in consensus.ResultsContrast between gray and white matter (p ≤ 0.02), the lesion (p ≤ 0.031) or hyperintense extension to the ventricle (p ≤ 0.021) and white matter was significantly higher in 2D than in 3D FLAIR sequences. In the visual analysis there was no difference between 2D and 3D sequences.ConclusionConventional 2D FLAIR sequences yield a higher image contrast compared to the employed 3D FLAIR sequence in patients with FCDs. Potential advantages of 3D imaging using surface rendering or automated techniques for lesion detection have to be further elucidated.Copyright © 2015 Elsevier B.V. All rights reserved.

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