• Oncology · Jan 2018

    Interim Results of a Phase II Study of Hypofractionated Radiotherapy with Concurrent Temozolomide Followed by Adjuvant Temozolomide in Patients over 70 Years Old with Newly Diagnosed Glioblastoma.

    • Mehran Yusuf, Beatrice Ugiliweneza, Mark Amsbaugh, Maxwell Boakye, Brian Williams, Megan Nelson, Eyas M Hattab, Shiao Woo, and Eric Burton.
    • Department of Radiation Oncology and the James Graham Brown Cancer Center, University of Louisville Hospital, Louisville, Kentucky, USA.
    • Oncology. 2018 Jan 1; 95 (1): 39-42.

    ObjectiveIn this phase II study, we investigate clinical outcomes and tolerability of hypofractionated radiotherapy (HRT) combined with temozolomide (TMZ) to treat elderly patients with glioblastoma (GBM).MethodsPatients 70 years of age or older with newly diagnosed GBM received HRT to a dose of 34 Gy given in ten fractions over 2 weeks, delivered with concurrent and adjuvant TMZ.ResultsIn this interim analysis, ten patients were enrolled on trial from 12/1/2015 to 4/5/2017. With a median follow-up of 9 months (range 3-12 months), median progression-free survival (PFS) was 6 months. The median overall survival (OS) has not been reached. Estimated 1-year OS and PFS rates were 53.3 and 44.4%, respectively. All patients completed the full course of RT, with no patients developing grade 3 or higher adverse events from treatment.ConclusionsThe preliminary results of our phase II trial suggest HRT delivered over 2 weeks with concurrent and adjuvant TMZ is well tolerated in elderly patients with GBM without compromising clinical outcomes.© 2018 S. Karger AG, Basel.

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