Thrombocytopenia-Associated Multiple Organ Failure and Acute

Critical care clinics · Oct 2015

Review

Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.

Thrombocytopenia-associated multiple organ failure (TAMOF) is a clinical phenotype that encompasses a spectrum of syndromes associated with disseminated microvascular thromboses, such as the thrombotic microangiopathies thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) and disseminated intravascular coagulation (DIC). Autopsies findings in TTP, HUS, or DIC reveal specific findings that can differentiate these 3 entities. ⋯ Tissue factor is the major protease that drives the pathology of DIC. Acute kidney injury (AKI) is a common feature in patients with TAMOF.

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- Trung C Nguyen, Miguel A Cruz, and Joseph A Carcillo.
- Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Center for Translational Research on Inflammatory Diseases (CTRID), Michael DeBakey VA Medical Center, Houston, TX 77030, USA. Electronic address: tcnguyen@texaschildrenshospital.org.
- Crit Care Clin. 2015 Oct 1; 31 (4): 661-74.
AbstractThrombocytopenia-associated multiple organ failure (TAMOF) is a clinical phenotype that encompasses a spectrum of syndromes associated with disseminated microvascular thromboses, such as the thrombotic microangiopathies thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) and disseminated intravascular coagulation (DIC). Autopsies findings in TTP, HUS, or DIC reveal specific findings that can differentiate these 3 entities. Von Willebrand factor and ADAMTS-13 play a central role in TTP. Shiga toxins and the complement pathway are vital in the development of HUS. Tissue factor is the major protease that drives the pathology of DIC. Acute kidney injury (AKI) is a common feature in patients with TAMOF.Copyright © 2015 Elsevier Inc. All rights reserved.

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Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.

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