-
- T Sugiura and Y Ariyoshi.
- Dept. of Internal Medicine, Aichi Cancer Center, Nagoya, Japan.
- Gan To Kagaku Ryoho. 1992 Nov 1; 19 (13): 2140-5.
AbstractCPT-11 and Topotecan are a new semisynthetic derivative of CPT, and have been shown to inhibit DNA topoisomerase I and to have a strong antitumor activity with low toxicity against murine tumor. On the other hard, the new antitumor compounds, NC-190 and IST-622 have been shown to inhibit DNA topoisomerase II, and the clinical study are currently under progress. A phase II study of CPT-11 demonstrated that CPT-11 was a very active agent which a acceptable toxicities against patient with advanced non-small cell lung cancer and small cell lung cancer.
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