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Asia Pac J Clin Oncol · Mar 2012
Pilot study evaluating the role of cardiac magnetic resonance imaging in monitoring adjuvant trastuzumab therapy for breast cancer.
- Claire Lawley, Camilla Wainwright, Eva Segelov, Jodi Lynch, Jane Beith, and Jane McCrohon.
- St Vincent's Hospital Clinical School, University of New South Wales, Sydney, New South Wales, Australia. claire.lawley@student.unsw.edu.au
- Asia Pac J Clin Oncol. 2012 Mar 1; 8 (1): 95-100.
AimTo explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI).MethodsThe cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater than 6 months previously was evaluated using MRI and comparing this with symptoms and routine echocardiography.ResultsEvidence of myocardial tissue damage was seen in two women in the absence of functional change or previous cardiac symptoms.ConclusionTissue characterization using cMRI may provide a useful tool in defining trastuzumab induced cardiotoxicity.© 2012 Blackwell Publishing Asia Pty Ltd.
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