• Onkologie · Jan 2012

    Review

    First-line therapy of mutated non-small cell lung cancer: an update.

    • Jan Stöhlmacher-Williams.
    • Medizinische Klinik und Poliklinik I, Fetscherstrasse 74, Dresden, Germany. jan.stoehlmacher@uniklinikum-dresden.de
    • Onkologie. 2012 Jan 1; 35 (5): 293-9.

    AbstractCurrently, many treatment options and new targets for cancer therapies for patients with advanced non-small cell lung cancer (NSCLC) are being evaluated. This article discusses in detail the significance of first-line and second-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and inhibitors of the vascular endothelial growth factor receptor (VEGFR) and EML4-ALK. Furthermore, the article summarizes the implications and future prospects of using molecular testing in the field of NSCLC with focus on EGFR mutations, KRAS mutation, EML4-ALK fusion gene detection, and EGFR expression.Copyright © 2012 S. Karger AG, Basel.

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