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Review Case Reports
Brentuximab vedotin desensitization in a patient with refractory Hodgkin's lymphoma.
- Anubha Arora, Vijaya Raj Bhatt, Susanne Liewer, James O Armitage, and R Gregory Bociek.
- Department of Obstetrics and Gynecology, King George's Medical College, Lucknow, India.
- Eur. J. Haematol. 2015 Oct 1; 95 (4): 361-4.
AbstractBrentuximab vedotin has emerged as a useful treatment option for relapsed or refractory Hodgkin's lymphoma; however, uncommon cases of anaphylactic reactions may require its permanent discontinuation. We report a 29-yr-old woman with refractory Hodgkin's lymphoma, who developed an anaphylactic reaction during the second dose of brentuximab vedotin. A 12-step desensitization protocol was followed; after premedicating with antihistaminic agents, methylprednisolone and montelukast, a total dose of 156 mg of brentuximab vedotin (1.8 mg/kg) was given as three infusions with increasing rate and concentration. Such desensitization protocol can allow safe administration of brentuximab vedotin and may have a broader applicability in managing hypersensitivity reactions with other monoclonal antibodies. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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