• Jonathan B Koea, Dennis Leung, Jonathan J Lewis, and Murray F Brennan.
• Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
• Ann. Surg. Oncol. 2003 May 1; 10 (4): 432-40.

BackgroundWe attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma.MethodsA total of 951 patients with primary, localized soft tissue extremity sarcoma were followed up prospectively. Patient- and tumor-related variables, including histopathologic type, were used to identify independent prognostic factors for the study end points of local recurrence, distant recurrence, and disease-specific survival.ResultsThere were 137 local recurrences, and significant adverse prognostic factors for local recurrence were patient age >50 years, microscopically positive margins, and malignant peripheral nerve tumor. Adverse prognostic factors for distant recurrence (200 patients) were tumor size >5 cm, tumors beneath the investing fascia, high tumor grade, and leiomyosarcoma. Of the 199 patients who died of disease-related causes, patient age >50 years, tumors beneath the investing fascia, high tumor grade, microscopically positive margin, tumor size >5 cm, leiomyosarcoma, and malignant peripheral nerve tumor were adverse prognostic factors.ConclusionsThese data suggest that differences in biological behavior may exist between sarcoma histotypes and deserve further study.

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