• Head & neck · Mar 2008

    Concurrent chemoradiotherapy with weekly paclitaxel and carboplatin for locally advanced head and neck cancer: Long-term follow-up of a Brown University Oncology Group Phase II Study (HN-53).

    • Prakash B Chougule, Muhammad S Akhtar, Ritesh Rathore, James Koness, Robert McRae, Peter Nigri, Kathie Radie-Keane, Teresa Kennedy, Harold J Wanebo, and Neal Ready.
    • Department of Radiation Oncology, Rhode Island Hospital, Providence, Rhode Island, USA.
    • Head Neck. 2008 Mar 1; 30 (3): 289-96.

    BackgroundA phase II study was conducted using concurrent paclitaxel, carboplatin, and external beam radiotherapy (RT) in patients with advanced head and neck cancer.MethodsForty-three patients (stage III, n = 12; stage IV, n = 31) were treated with 8 cycles of weekly paclitaxel (60 mg/m(2)), carboplatin (area under the curve [AUC] = 1), and RT (1.8 Gy daily; total dose, 66-72 Gy). Patients with initially palpable lymph nodes underwent neck dissection.ResultsThe overall clinical response rate was 91% (65% complete, 26% partial). Severe mucositis occurred in 37 (90%) patients, necessitating hospitalization in 13 (31%) patients. With a median follow-up of 49 months, the locoregional and distant failure rates were 26% and 21%, respectively.ConclusionsConcurrent paclitaxel, carboplatin, and RT for advanced head and neck cancer results in high complete response rates. Long-term follow-up has revealed the curative potential of this regimen, though the doses used resulted in unacceptable toxicity.(c) 2007 Wiley Periodicals, Inc. Head Neck 2008.

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