• Reproductive sciences · Sep 2008

    Expression of c-kit and platelet-derived growth factor receptors in ovarian granulosa cell tumors.

    • Rodney P Rocconi, Kellie S Matthews, Kristopher J Kimball, Michael G Conner, Allyson C Baker, and Mack N Barnes.
    • Department of Obstetrics and Gynecology, University of South Alabama Mitchell Cancer Institute, Mobile, Alabama 36607, USA. rocconi@usouthal.edu
    • Reprod Sci. 2008 Sep 1; 15 (7): 673-7.

    ObjectiveThis study aimed at evaluating the expression of tyrosine kinase receptors c-kit, (platelet-derived growth factor receptor-alpha (PDGFR-alpha), and PDGFR-beta in ovarian granulosa cell tumors (GCTs).Study DesignPrimary ovarian GCT specimens were obtained for immunohistochemical staining.The expressions of c-kit, PDGFR-alpha, and PDGFR-beta were analyzed and scored by a semiquantitative (SQ) method. Normal ovarian tissue from the same patients' specimens served as internal controls.ResultsA total of 21 specimens were available for evaluation. C-kit was expressed in only 2 samples, whereas both PDGFR-alpha and PDGFR-beta stained positive in 100% of tumors. PDGFR targets demonstrated strong positive expression in intensity and amount of tissue stained. Normal ovarian tissue demonstrated complete absence of staining for all 3 antibodies evaluated.ConclusionsThe data demonstrated significant expression of PDGFR targets of imatinib mesylate in GCTs, whereas normal ovarian tissues had a complete absence of staining.This expression profile provides the rationale to investigate the role of imatinib mesylate in PDGFR-positive GCTs.

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