• Mol. Cell. Biochem. · Nov 2003

    Review

    Antimicrotubular drugs binding to vinca domain of tubulin.

    • Suvroma Gupta and Bhabatarak Bhattacharyya.
    • Department of Biochemistry, Bose Institute, Centenary Campus, Calcutta, India.
    • Mol. Cell. Biochem. 2003 Nov 1; 253 (1-2): 41-7.

    AbstractStudies on vinca domain binding drugs were done in great details by a number of workers as it is recognized as a potential target for anticancer drug development. Their structures, properties, mode of action, success and failures as potential anticancer drug have been discussed in short details in this review. Among these drugs rhizoxin and maytansine are competitive inhibitors, and bind at the vinblastine binding site of tubulin where as others are non-competitive inhibitors. Besides binding, these drugs also differ in the extent of GTP hydrolysis, GTP exchange and in the stabilization of colchicine binding site. The toxicity level of these drugs towards the host cells and the extent of efflux of drugs by the P-glycoprotein mediated pump are also discussed.

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