• Cancer research · Mar 1987

    Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.

    • D J FitzGerald, M J Bjorn, R J Ferris, J L Winkelhake, A E Frankel, T C Hamilton, R F Ozols, M C Willingham, and I Pastan.
    • Cancer Res. 1987 Mar 1; 47 (5): 1407-10.

    AbstractAn immunotoxin composed of an antibody to the human transferrin receptor (454A12) and ricin A chain (RTA) was shown to inhibit the growth of NIH:OVCAR-3 tumors in a nude mouse model of human ovarian cancer. Inhibition of tumor growth by 454A12-RTA was related to the dose administered. The antitumor activity of the immunotoxin was blocked by coinjection of excess antibody with immunotoxin. An immunotoxin made using 454A12 and recombinant ricin A chain (rRTA) had an activity similar to that made with native RTA. The administration of 10 micrograms or greater of the immunotoxin 454A12-RTA/rRTA had significant antitumor activity. The injection of 30 micrograms of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 micrograms of the 454A12 antibody had no antitumor activity.

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