• Martina Locatelli, Mario Grassi, Valentina Saba, Licia Iacovello, Augusto di Castelnuovo, Giovanni de Gaetano, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, DelodoviciMaria LuisaMLUnità di Neurologia, Ospedale di Circolo, Università dell'Insubria, Varese, Italia., Lucia Princiotta Cariddi, Alessia Giossi, Andrea Zini, Maurizio Paciaroni, Monica Acciarresi, Cristiano Azzini, Alessandro De Vito, Massimo Gamba, Mauro Magoni, Massimo Del Sette, Antonella Toriello, Carlo Gandolfo, Cinzia Finocchi, Domenico Marco Bonifati, Rossana Tassi, Giuseppe Martini, Anna Cavallini, Andrea Morotti, Sonia Bonacina, Valentina Mazzoleni, Debora Pezzini, Alberto Chiti, Rocco Salvatore Calabrò, Rosa Musolino, Paolo La Spina, Francesco Grillo, Giampaolo Tomelleri, Corrado Lodigiani, Marco Ritelli, Marina Colombi, Alessandro Padovani, Alessandro Pezzini, and Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators.
• Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italia.
• J. Neurol. Neurosurg. Psychiatr. 2021 Oct 1; 92 (10): 1068-1071.

ObjectiveTo investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).MethodsWe performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).ResultsWe analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).ConclusionsOur findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

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