• Ned Tijdschr Geneeskd · Dec 2002

    Review

    [Sequential analysis in clinical and epidemiological research].

    • I van der Tweel and M Schipper.
    • Universiteit Utrecht, Centrum voor Biostatistiek, Postbus 80.058, 3508 TB Utrecht. i.vandertweel@bio.uu.nl
    • Ned Tijdschr Geneeskd. 2002 Dec 7; 146 (49): 2348-52.

    AbstractIn clinical trials and epidemiological studies, interim analyses are usually performed for ethical or economical reasons, although efficiency aspects can also be a reason. The analysis is referred to as group-sequential analysis or continuous-sequential analysis, dependent on the number of interim analyses performed. Repeated testing of cumulative data requires an adjustment to the significance level or type I error alpha of a statistical test. On average a (group-)sequential analysis of a clinical or epidemiological study requires less patients than the analysis of a fixed-sample study.

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