• J. Neurol. Neurosurg. Psychiatr. · Jul 2000

    Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis.

    • R Giess, M Naumann, E Werner, R Riemann, M Beck, I Puls, C Reiners, and K V Toyka.
    • Department of Neurology, Bayerische Julius-Maximilians- University, Wuerzburg, Germany.
    • J. Neurol. Neurosurg. Psychiatr. 2000 Jul 1; 69 (1): 121-3.

    AbstractSialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.

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