• Bruce S Spottiswoode, Xiaodong Zhong, Christine H Lorenz, Bongani M Mayosi, Ernesta M Meintjes, and Frederick H Epstein.
• UCT/MRC Medical Imaging Research Unit, University of Cape Town, South Africa.
• J Magn Reson Imaging. 2008 May 1; 27 (5): 1019-27.

PurposeTo track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE).Materials And MethodsSlice following (SF) has previously been developed for 2D myocardial tagging to compensate for the effect of through-plane motion on 2D tissue tracking. By incorporating SF into a cine DENSE sequence, and applying displacement encoding in three orthogonal directions, we demonstrate the ability to track discrete elements of a slice of myocardium in 3D as the heart moves through the cardiac cycle. The SF cine DENSE tracking algorithm was validated on a moving phantom, and the effects of through-plane motion on 2D cardiac strain were investigated in six healthy subjects.ResultsA through-plane tracking accuracy of 0.46 +/- 0.32 mm was measured for a typical range of myocardial motion using a rotating phantom. In vivo 3D measurements of cardiac motion were consistent with prior myocardial tagging results. Through-plane rotation in a mid-ventricularshort-axis view was shown to decrease the magnitude of the 2D end-systolic circumferential strain by 3.91 +/- 0.43% and increase the corresponding radial strain by 6.01 +/- 1.07%.ConclusionSlice followed cine DENSE provides an accurate method for 3D tissue tracking.(c) 2008 Wiley-Liss, Inc.

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