• Victor Speidel, Anna Conen, Valentin Gisler, Christoph A Fux, and Sebastian Haubitz.
• Department of Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Aarau, Switzerland; University Clinic of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland; Department of Emergency Medicine, Oberaargau Regional Hospital, Langenthal, Switzerland. Electronic address: v.speidel@sro.ch.
• Ultrasound Med Biol. 2021 Apr 1; 47 (4): 896-901.

AbstractLung ultrasound (LUS) has shown promising diagnostic potential in different pulmonary conditions. We evaluated the diagnostic accuracy of LUS for pulmonary COVID-19. In this prospective cohort study at a Swiss tertiary care center, patients hospitalized with suspected COVID-19 were scanned using a 12-zone protocol. Association of a summation score (0-36 points) with the final diagnosis was tested using the area under the receiver operating characteristic curve and sensitivity and specificity at different cutoff points. Of the 49 participants, 11 (22%) were later diagnosed with COVID-19. LUS score showed excellent diagnostic performance, with an odds ratio of 1.30 per point (95% confidence interval [CI], 1.09-1.54, p = 0.003) and an area under the curve of 0.85 (95% CI, 0.71-0.99). At a cutoff of 8/36 points, 10 of 11 participants later diagnosed with COVID-19 were correctly predicted (sensitivity 91%, 95% CI, 59%-100%), and 29 of the 38 who were not diagnosed with COVID-19 were correctly ruled out (specificity 76%, 95% CI, 60%-89%). LUS demonstrated promising discriminatory potential in people hospitalized with suspected COVID-19.Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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