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- Katia da Hora, Samuel Santos Valença, and Luís Cristóvão Porto.
- Departamento de Histologia e Embriologia, IBRAG, UERJ, Rio de Janeiro, Brazil.
- Exp. Lung Res. 2005 Oct 1; 31 (8): 759-70.
AbstractAlveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor of metalloproteinase (TIMP)-2. Cigarette smoke (CS)-exposed mice showed a progressive increase in numbers of alveolar macrophages (AMs) up to 10 days. MMP-12 was increased in AMs compared to the control group. The number of AMs with TNF-alpha and TIMP-2 labeling was higher at 5 days but decreased at 10 days. Short-term CS exposure induced pulmonary inflammation with major participation of MMP-12-positive AMs.
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