• Eur. J. Clin. Invest. · Oct 2012

    Review

    Genetic study on developmental dysplasia of the hip.

    • Dongquan Shi, Jin Dai, Shiro Ikegawa, and Qing Jiang.
    • The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China.
    • Eur. J. Clin. Invest. 2012 Oct 1; 42 (10): 1121-5.

    BackgroundDevelopmental dysplasia of the hip (DDH) is a developmental disorder of the hip joint that results in an abnormal socket of the femoral head, ranging from instability, subluxation and complete dislocation of the hip joint. DDH has a considerable genetic component.DesignWe reviewed the recent progress on genetic study of DDH.ResultsBy linkage and case-control association studies, DDH loci have been identified with several susceptibility genes that involve in bone and joint biology; however, no unequivocal genes with global significance have been detected. The current problem of the association study in DDH is discussed.ConclusionsBy advanced technologies and international collaboration, we need to find more susceptibility genes and bridge the gap between genetic evidence and molecular mechanisms.© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.

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