• Brain Nerve · May 2020

    Review

    [Factors Influencing Brain Interstitial Fluid Concentrations of Amyloid β and Tau].

    • Masanori Kurihara, Taro Bannai, and Atsushi Iwata.
    • Department of Neurology, Graduate School of Medicine, The University of Tokyo.
    • Brain Nerve. 2020 May 1; 72 (5): 525-531.

    AbstractIn patients with Alzheimer's disease, the brain interstitial space is an important place where amyloid-β oligomers and aggregates exist. Although tau aggregates are observed inside neurons, extracellular brain interstitial fluid tau has drawn attention because of increasing understanding of cell-to-cell propagation of tau aggregation. In this review, we summarize our current understanding of factors influencing brain interstitial fluid concentrations of amyloid-β and tau, mainly focusing on known epidemiological risk factors for Alzheimer's disease.

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