• Leukemia research · Aug 2005

    Case Reports

    Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML). Outcome of discontinuation of imatinib therapy after achieving a molecular remission.

    • Ridvan Ali, Fahir Ozkalemkaş, Tülay Ozçelik, Vildan Ozkocaman, Ulkü Ozan, Yalçin Kimya, Nilgün Köksal, Tuna Gülten, Tahsin Yakut, and Ahmet Tunali.
    • Division of Hematology, Department of Internal Medicine, Uludag University School of Medicine, Bursa, Turkey. ridvanali@uludag.edu.tr
    • Leuk. Res. 2005 Aug 1; 29 (8): 971-3.

    AbstractBecause of the teratogenicity data in rats, it is recommended that women treated with imatinib should be aware of the potential teratogenicity of imatinib and effective contraception should be used during imatinib therapy to prevent pregnancy. We describe successful pregnancy and delivery, without any congenital anomaly, in a patient with CML under treatment of imatinib. The fetus had been exposed to imatinib for 8 weeks. The patient remained off treatment during gestation and cytogenetic relapse of CML (5 months after discontinuation of imatinib therapy) developed at seventh month of gestation.

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