• Diabetes Metab Syndr · Jul 2020

    Review

    SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects.

    • Konstantinos Michalakis and Ioannis Ilias.
    • Private Practice, 10-12 Dorylaiou Str, Athens, GR11521, Greece. Electronic address: kostismichalakis@hotmail.com.
    • Diabetes Metab Syndr. 2020 Jul 1; 14 (4): 469-471.

    Backround And AimsAccording to the World Obesity Federation, "obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)"; additionally the Centres for Disease Control and Prevention reported that "people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness". Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.MethodsPubmed search on obesity and SARS-CoV-2 infection.ResultsWe present "mechanistic" obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.ConclusionObesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.

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