• Brain connectivity · Jun 2016

    Underconnected, But Not Broken? Dynamic Functional Connectivity MRI Shows Underconnectivity in Autism Is Linked to Increased Intra-Individual Variability Across Time.

    • Maryam Falahpour, Wesley K Thompson, Angela E Abbott, Afrooz Jahedi, Mark E Mulvey, Michael Datko, Thomas T Liu, and Ralph-Axel Müller.
    • 1 Center for Functional MRI, Department of Radiology, University of California , San Diego, California.
    • Brain Connect. 2016 Jun 1; 6 (5): 403-14.

    AbstractAutism spectrum disorder (ASD) is characterized by core sociocommunicative impairments. Atypical intrinsic functional connectivity (iFC) has been reported in numerous studies of ASD. A majority of findings has indicated long-distance underconnectivity. However, fMRI studies have thus far exclusively examined static iFC across several minutes of scanning. We examined temporal variability of iFC, using sliding window analyses in selected high-quality (low-motion) consortium datasets from 76 ASD and 76 matched typically developing (TD) participants (Study 1) and in-house data from 32 ASD and 32 TD participants. Mean iFC and standard deviation of the sliding window correlation (SD-iFC) were computed for regions of interest (ROIs) from default mode and salience networks, as well as amygdala and thalamus. In both studies, ROI pairings with significant underconnectivity (ASD

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