• Shi-Xiong Liang, Xiao-Dong Zhu, Zhi-Yong Xu, Ji Zhu, Jian-Dong Zhao, Hai-Jie Lu, Yun-Li Yang, Long Chen, An-Yu Wang, Xiao-Long Fu, and Guo-Liang Jiang.
• Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China.
• Int. J. Radiat. Oncol. Biol. Phys. 2006 Jun 1; 65 (2): 426-34.

PurposeTo identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation.Methods And MaterialsThe data of 109 primary liver carcinomas (PLC) treated with hypofractionated three-dimensional conformal radiation therapy (3D-CRT) were analyzed. Seventeen patients were diagnosed with RILD and 13 of 17 died of it.ResultsThe risk factors for RILD were late T stage, large gross tumor volume, presence of portal vein thrombosis, association with Child-Pugh Grade B cirrhosis, and acute hepatic toxicity. Multivariate analyses demonstrated that the severity of hepatic cirrhosis was a unique independent predictor. For Child-Pugh Grade A patients, the hepatic radiation tolerance was as follows: (1) Mean dose to normal liver (MDTNL) of 23 Gy was tolerable. (2) For cumulative dose-volume histogram, the tolerable volume percentages would be less than: V5 of 86%, V10 of 68%, V15 of 59%, V20 of 49%, V25 of 35%, V30 of 28%, V35 of 25%, and V40 of 20%. (3) Tolerable MDTNL could be estimated by MDTNL (Gy) = -1.686 + 0.023 * normal liver volume (cm3).ConclusionThe predominant risk factor for RILD was the severity of hepatic cirrhosis. The hepatic tolerance to radiation could be estimated by dosimetric parameters.

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