-
- Jérémy Beaumont, Giulio Gambarota, Hervé Saint-Jalmes, Oscar Acosta, Jean-Christophe Ferré, Parnesh Raniga, and Jurgen Fripp.
- Univ Rennes, CRLCC Eugene Marquis, Inserm, LTSI-UMR1099, Rennes, France.
- Magn Reson Med. 2021 Mar 1; 85 (3): 1364-1378.
PurposeTo demonstrate that fluid and white matter suppression (FLAWS) imaging can be used for high-resolution T1 mapping with low transmitted bias field ( B 1 + ) sensitivity at 7T.MethodsThe FLAWS sequence was optimized for 0.8-mm isotropic resolution imaging. The theoretical accuracy and precision of the FLAWS T1 mapping was compared with the one of the magnetization-prepared two rapid gradient echoes (MP2RAGE) sequence optimized for low B 1 + sensitivity. FLAWS images were acquired at 7T on six healthy volunteers (21 to 48 years old; two women). MP2RAGE and saturation-prepared with two rapid gradient echoes (SA2RAGE) datasets were also acquired to obtain T1 mapping references and B 1 + maps. The contrast-to-noise ratio (CNR) between brain tissues was measured in the FLAWS-hco and MP2RAGE-uni images. The Pearson correlation was measured between the MP2RAGE and FLAWS T1 maps. The effect of B 1 + on FLAWS T1 mapping was assessed using the Pearson correlation.ResultsThe FLAWS-hco images were characterized by a higher brain tissue CNR ( CNR WM / GM = 5.5 , CNR WM / CSF = 14.7 , CNR GM / CSF = 10.3 ) than the MP2RAGE-uni images ( CNR WM / GM = 4.9 , CNR WM / CSF = 6.6 , CNR GM / CSF = 3.7 ). The theoretical accuracy and precision of the FLAWS T1 mapping ( acc = 91.9 % ; prec = 90.2 % ) were in agreement with those provided by the MP2RAGE T1 mapping ( acc = 90.0 % ; prec = 86.8 % ). A good agreement was found between in vivo T1 values measured with the MP2RAGE and FLAWS sequences (r = 0.91). A weak correlation was found between the FLAWS T1 map and the B 1 + map within cortical gray matter and white matter segmentations ( r WM = - 0.026 ; r GM = 0.081 ).ConclusionThe results from this study suggest that FLAWS is a good candidate for high-resolution T1 -weighted imaging and T1 mapping at the field strength of 7T.© 2020 International Society for Magnetic Resonance in Medicine.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.