• Sung-Min Cho, Lavienraj Premraj, Jonathon Fanning, Samuel Huth, Adrian Barnett, Glenn Whitman, Rakesh C Arora, Denise Battaglini, Diego Bastos Porto, HuiMahn Choi, Jacky Suen, BassiGianluigi LiGLCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.Faculty of Medicine University of Queensland, Brisbane, QLD, Australia.Australian Centre for Health Services Innovation (AusHSI) and Centre for Healthca, John F Fraser, Chiara Robba, and Matthew Griffee.
• Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
• Crit. Care Med. 2021 Dec 1; 49 (12): e1223e1233e1223-e1233.

ObjectivesStroke has been reported in observational series as a frequent complication of coronavirus disease 2019, but more information is needed regarding stroke prevalence and outcomes. We explored the prevalence and outcomes of acute stroke in an international cohort of patients with coronavirus disease 2019 who required ICU admission.DesignRetrospective analysis of prospectively collected database.SettingA registry of coronavirus disease 2019 patients admitted to ICUs at over 370 international sites was reviewed for patients diagnosed with acute stroke during their stay.PatientsPatients older than 18 years old with acute coronavirus disease 2019 infection in ICU.InterventionsNone.Measurements And Main ResultsOf 2,699 patients identified (median age 59 yr; male 65%), 59 (2.2%) experienced acute stroke: 0.7% ischemic, 1.0% hemorrhagic, and 0.5% unspecified type. Systemic anticoagulant use was not associated with any stroke type. The frequency of diabetes, hypertension, and smoking was higher in patients with ischemic stroke than in stroke-free and hemorrhagic stroke patients. Extracorporeal membrane oxygenation support was more common among patients with hemorrhagic (56%) and ischemic stroke (16%) than in those without stroke (10%). Extracorporeal membrane oxygenation patients had higher cumulative 90-day probabilities of hemorrhagic (relative risk = 10.5) and ischemic stroke (relative risk = 1.7) versus nonextracorporeal membrane oxygenation patients. Hemorrhagic stroke increased the hazard of death (hazard ratio = 2.74), but ischemic stroke did not-similar to the effects of these stroke types seen in noncoronavirus disease 2019 ICU patients.ConclusionsIn an international registry of ICU patients with coronavirus disease 2019, stroke was infrequent. Hemorrhagic stroke, but not ischemic stroke, was associated with increased mortality. Further, both hemorrhagic stroke and ischemic stroke were associated with traditional vascular risk factors. Extracorporeal membrane oxygenation use was strongly associated with both stroke and death.Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

19 keywords...

hide…