• Edmund Pribitkin, Oren Friedman, Brian O'Hara, Mary F Cunnane, David Levi, Marc Rosen, William M Keane, and Robert T Sataloff.
• Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, 1721 Pine Street, Philadelphia, PA, USA.
• Laryngoscope. 2003 Dec 1; 113 (12): 2095-101.

Objectives/HypothesisTo delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.Study DesignRetrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals.Material And MethodsThe charts of 16 patients with upper aerodigestive tract amyloidosis identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study.ResultsSixteen patients (9 male and 7 female, with an average age of 49.8 years) with upper aerodigestive tract amyloidosis were identified. The most common site of amyloid involvement was the larynx. Consequently, patients most commonly presented with hoarseness (14 of 16). All patients underwent surgical removal of the amyloid deposits. Fourteen patients had primary localized amyloidosis. Two experienced systemic involvement. Seven of the 16 patients developed recurrences requiring further treatment.ConclusionsAmyloidosis of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow-up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.

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