• Shouko Ono, Mototsugu Kato, Kikuko Takagi, Junichi Kodaira, Kanako Kubota, Yoshihiro Matsuno, Yoshito Komatsu, and Masahiro Asaka.
• Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan. onosho@med.hokudai.ac.jp
• J. Gastroenterol. Hepatol. 2010 Apr 1; 25 (4): 804-9.

Background And AimAccording to a few recent reports on the long-term clinical outcome of gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma (MALT lymphoma); localized gastric MALT lymphoma generally has a favorable prognosis. However, the risk of metachronous gastric cancer has not been evaluated. In this study, we analyzed long-term outcomes of localized gastric MALT lymphoma including the incidence of metachronous gastric cancer.MethodsBetween April 1996 and May 2008, 60 patients (31 men and 29 women; mean age 58.1 years) with localized gastric MALT lymphoma (stage I and II(1) according to Lugano classification) were analyzed retrospectively.ResultsForty-eight patients (82.6%) achieved complete remission by eradication therapy. Radiation therapy was conducted on eight patients as second-line treatment, and all of them achieved remission. The median follow-up period was 76 months (range, 12-157 months). One patient had local relapse after remission for 5 years and three patients developed early gastric cancer without recurrence of lymphoma (5%). All of the three gastric cancers appeared in the same areas where MALT lymphoma had been eradicated.ConclusionEradication therapy and radiation therapy for localized gastric MALT lymphoma have a favorable long-term outcome, though regular follow-up endoscopy should be performed for detecting metachronous early gastric cancer.

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