• Siok-Hoon Ang, Benjamin Haaland, Sanchalika Acharyya, Minn M M Thu, Sai-Sakktee Krisna, Siok-Gek Hwang, Puay-Hoon Tan, Quan-Sing Ng, Daniel S W Tan, Wai-Meng Tai, Eng-Huat Tan, Wan-Teck Lim, and Mei-Kim Ang.
• Duke-NUS Graduate Medical School, Singapore.
• Head Neck. 2015 Nov 1; 37 (11): 1650-9.

BackgroundP16 and cyclin-D1 are cell cycle proteins commonly dysregulated in head and neck carcinoma. We assessed their expression, clinicopathological variables, and overall survival (OS) in oropharyngeal and hypopharyngeal squamous cell carcinoma (SCC).MethodsClinical characteristics and p16 and cyclin-D1 expression were evaluated in 101 patients with oropharyngeal SCC and 75 patients with hypopharyngeal SCC. Associations with OS were assessed using Cox regression and Kaplan-Meier analysis.ResultsCompared to oropharyngeal SCC, patients with hypopharyngeal SCC were older, men, ever-smokers with higher mean Charlson Comorbidity Index (CCI), lower p16 expression, and poorer median OS (24.8 vs 62.3 months; p < .01). In oropharyngeal SCC, CCI (p < .001), cyclin-D1 (hazard ratio [HR] = 3.55; p = .007), current smoking (HR = 5.72; p = .004), and former smoking (HR = 4.12; p = .035) were independently associated with OS. In hypopharyngeal SCC, only nodal and Eastern Cooperative Oncology Group status were associated with OS.ConclusionIn oropharyngeal SCC, cyclin-D1 expression is correlated with survival, whereas smoking status and CCI may allow further stratification of outcome.© 2014 Wiley Periodicals, Inc.

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