• Martina A Broglie, Sandro J Stoeckli, Rafael Sauter, Philippe Pasche, Antoine Reinhard, Laurence de Leval, Gerhard F Huber, Thomas F Pezier, Alex Soltermann, Roland Giger, Andreas Arnold, Matthias Dettmer, Andre Arnoux, Martin Müller, Stefan Spreitzer, Florian Lang, Mathieu Lutchmaya, Edouard Stauffer, Vittoria Espeli, Francesco Martucci, Massimo Bongiovanni, Diana Foerbs, and Wolfram Jochum.
• Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
• Head Neck. 2017 Oct 1; 39 (10): 2004-2015.

BackgroundKnowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC.MethodsRetrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors.ResultsThe 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%).ConclusionNonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.© 2017 Wiley Periodicals, Inc.

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