• J Surg Oncol · Dec 2011

    Review

    Systemic therapy for advanced gastrointestinal stromal tumors: beyond imatinib.

    • Edward J Kim and Mark M Zalupski.
    • Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan 48109-5934, USA.
    • J Surg Oncol. 2011 Dec 1; 104 (8): 901-6.

    AbstractProgression on first-line therapy with imatinib in gastrointestinal stromal tumors (GIST) is caused by either initial resistance or more often a secondary mutation in tyrosine kinases KIT or PDGFR. Therapies in development for imatinib-resistant GIST include agents that target KIT/PDGFR with greater potency or possess broader kinase inhibition profiles including VEGFR. To circumvent secondary mutations in KIT/PDGFR, inhibition of the downstream signaling in PI3K/Akt/mTOR pathway and enhanced degradation of KIT/PDGFR are also under investigation.Copyright © 2011 Wiley Periodicals, Inc.

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