• Urologic oncology · Dec 2016

    Review

    Making urothelial carcinomas less immune to immunotherapy.

    • Jorge D Ramos and Evan Y Yu.
    • Department of Medicine, University of Washington School of Medicine, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
    • Urol. Oncol. 2016 Dec 1; 34 (12): 534-537.

    AbstractThe success of immune checkpoint inhibitors in advanced urothelial carcinoma provides patients with the prospect for durable objective responses. However, the majority of patients do not respond to immune checkpoint blockade. Several potential predictive biomarkers of response have been evaluated in hopes of better identifying likely responders, though each has been shown to have limitations. Going forward, development of reliable predictive biomarkers is imperative. Likewise, innovative treatment combination approaches to convert non-responders to responders are essential to continue making progress in the field.Copyright © 2016 Elsevier Inc. All rights reserved.

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