• Qingxian Cai, Deliang Huang, Pengcheng Ou, Hong Yu, Zhibin Zhu, Zhang Xia, Yinan Su, Zhenghua Ma, Yiming Zhang, Zhiwei Li, Qing He, Lei Liu, Yang Fu, and Jun Chen.
• National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
• Allergy. 2020 Jul 1; 75 (7): 1742-1752.

BackgroundThe clinical characteristics of novel coronavirus disease (COVID-2019) patients outside the epicenter of Hubei Province are less understood.MethodsWe analyzed the epidemiological and clinical features of all COVID-2019 cases in the only referral hospital in Shenzhen City, China, from January 11, 2020, to February 6, 2020, and followed until March 6, 2020.ResultsAmong the 298 confirmed cases, 233 (81.5%) had been to Hubei, while 42 (14%) did not have a clear travel history. Only 218 (73.15%) cases had a fever as the initial symptom. Compared with the nonsevere cases, severe cases were associated with older age, those with underlying diseases, and higher levels of C-reactive protein, interleukin-6, and erythrocyte sedimentation rate. Slower clearance of the virus was associated with a higher risk of progression to critical condition. As of March 6, 2020, 268 (89.9%) patients were discharged and the overall case fatality ratio was 1.0%.ConclusionsIn a designated hospital outside Hubei Province, COVID-2019 patients could be effectively managed by properly using the existing hospital system. Mortality may be lowered when cases are relatively mild, and there are sufficient medical resources to care and treat the disease.© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

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