• I Gunduz, A Kondylis, G Jaccard, J-M Renaud, R Hofer, L Ruffieux, and F Gadani.
• Philip Morris Products SA, Product Development, Rue des Usines 56, 2000 Neuchâtel, Switzerland. Electronic address: irfan.gunduz@pmi.com.
• Regul. Toxicol. Pharmacol. 2016 Apr 1; 76: 113-20.

AbstractThe evolution of the levels of tobacco-specific N-nitrosamines (TSNA), N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream (MS) cigarette smoke is investigated based on smoke and tobacco chemistry data of cigarette brands sold by Philip Morris International (PMI) between 2000 and 2014. A total of 315 cigarette samples representing a wide range of product and design characteristics manufactured by PMI between 2008 and 2014 were analyzed and compared to a previously published dataset of PMI brands manufactured in 2000. The data indicate that there is a substantial reduction of NNN and NNK levels in tobacco fillers and MS cigarette smoke per mg of tar and per mg of nicotine using Health Canada Intense (HCI) machine-smoking regime. This observed reduction in NNN and NNK levels in MS cigarette smoke is also supported by the downward trend observed on NNN and NNK levels in USA flue-cured Virginia and Burley tobacco lots from 2000 to 2014 crops, reflecting effectiveness of measures taken on curing and agricultural practices designed to minimize TSNA formation in tobacco. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

28 keywords...

hide…