• Clin. Chim. Acta · Feb 2019

    The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury.

    • Tie-Jiang Chen, Ming-Xia Ji, Zhi-Qiang Tao, Qing-Yang Fu, Kai Xiong, and Bin Cheng.
    • Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 322000, Zhejiang Province, China. Electronic address: hzhzzhoufeng@163.com.
    • Clin. Chim. Acta. 2019 Feb 1; 489: 53-57.

    BackgroundFibrinogen-like protein 2 (FGL2) is an inflammatory procoagulant protein. We discerned the impact of serum FGL2 on trauma severity and 30-day mortality in patients with traumatic brain injury (TBI).MethodsA total of 114 severe TBI patients were subjected to assessment of trauma severity using the Glasgow coma scale (GCS). Measurement of the serum concentrations of FGL2 was done. 114 matched control subjects for their age and sex were included for comparison of serum concentration of FGL2.ResultsThe concentration of FGL2 was dramatically increased in the patients as compared with the control subjects. FGL2 concentration was inversely correlated with GCS score among the patients. The non-survivors within 30 days exhibited substantially higher FGL2 concentrations than the alive. FGL2 concentrations discriminated the patients at risk of 30-day death with significantly high area under receiver operating characteristic curve. Serum FGL2 emerged as an independent predictor for mortality and overall survival at 30 days after head trauma.ConclusionsSerum FGL2 is a promising biomarker for assessing the severity and prognosis in severe TBI.Copyright © 2018 Elsevier B.V. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…