• Int. J. Cardiol. · Oct 2018

    Observational Study

    Statin exposure during first trimester of pregnancy is associated with fetal ventricular septal defect.

    • Ming-Sum Lee, Avetis Hekimian, Tanya Doctorian, and Lewei Duan.
    • Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, United States of America. Electronic address: mingsum.lee@kp.org.
    • Int. J. Cardiol. 2018 Oct 15; 269: 111-113.

    BackgroundA growing number of young women are exposed to statins during their first trimester of pregnancy. The goal of this study is to examine if first trimester statin exposure is associated with an increase in risk of fetal congenital cardiac anomalies.MethodsIn a cohort of 379,238 pregnancies, we examined the risk of fetal congenital cardiac anomalies in association with maternal exposure to statin therapy during the first trimester of pregnancy using logistic regression models and propensity score matching methods.Results280 women were exposed to statins. Congenital cardiac anomalies were present in 14 (5.0%) of pregnancies exposed to statin and 5282 (1.4%) of non-exposed pregnancies. First-trimester statin exposure was associated with an increased risk of ventricular septal defect (adjusted odds ratio [OR] 3.3, 95% confidence interval [CI]l 1.8-6.0, p < 0.001). This association was confirmed in an analysis using a propensity score-matched cohort (OR 4.7, 95% CI 2.0-10.8, p < 0.001).ConclusionsExposure to statins during the first trimester of pregnancy is associated with fetal ventricular septal defect.Copyright © 2018 Elsevier B.V. All rights reserved.

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