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Case Reports
Unusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia.
- P Blanco, J F Viallard, J Rivel, B Leng, and J L Pellegrin.
- Service de Médecine Interne, Hôpital du Haut-levêque, Avenue de Magellan, 33604 Pessac, France.
- J. Clin. Pathol. 2000 Nov 1; 53 (11): 882-4.
AbstractCryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously.
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